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Between 2017 and 2022, the mean annual out-of-pocket payment decreased for participants with and without diabetes (from $414 to $252 and from $212 to $157, respectively)

Others rely primarily on injections with periodic infusions for deeper support

The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Given the poorly characterized specificity of enzymes involved in thiamine transformation and the often unknown roles of genomics-identified isoenzymes, all human isoenzymes are included in Figure 3 when there is evidence that at least one isoenzyme can catalyze the reactions with thiamine or its derivatives

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& Lehuen, A