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The document now includes all sections from the template with current evidence-based citations

Its multifaceted role encompasses not only the regulation of vascular permeability and dilation but also extends to beneficial aspects such as enhancing neuronal access to vital nutrients, orchestrating cytoskeletal rearrangements, and promoting cell migration (McConnell et al

401 In addition, MDD is associated with significant decreases in astrocytic glutamate transporters and glutamine synthetase, impairing neurotransmission

Tesamorelin is FDA-approved for HIV-associated lipodystrophy

Some studies demonstrated that GST gene polymorphism carries have a positive correlation with brain cancer, Alzheimers disease, and Parkinsons disease development risk [54]

10.1039/c5ra26797h 290 WinterbournC