iih glp 1 Journal club: GLP-1 receptor agonists in idiopathic intracranial hypertension Idiopathic Intracranial Hypertension and the

Biomolecules 13 , 779 (2023)

Currently, in addition to LY3463251, several other GDF-15 agonists are being assessed in early-stage clinical trials, including NNC0247-0829 and JNJ-9090/CIN-109, among others

Fala 2015)

This strategy is the basis for many anticancer therapeutics, including chemotherapeutics, radiotherapies, and most small-molecule inhibitor-based therapies, which impair tumor metabolism and induce excessive ROS accumulation, inducing cell toxicity and death

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

Indeed, GLP-1 and analogues are known to form amphipathic -helix structures that are poorly soluble and prone to generate aggregates 33