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Regardless which of the two hypotheses more precisely reflects the underlying mechanisms, it is an important finding of basic electrophysiological research that a mismatch of depolarizing current (in particular I Na ) and I to , as well as distinct phases of bradycardia, are major drivers of arrhythmogenicity in BrS

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Albert CM, Chen PS, Anderson ME, Cain ME, Fishman GI, Narayan SM, Olgin JE, Spooner PM, Stevenson WG, Van Wagoner DR, Packer DL, Heart Rhythm Society Research Task F (2011) Full report from the first annual Heart Rhythm Society Research Forum: a vision for our research future, dream, discover, develop, deliver

Clinical research has generally demonstrated favorable tolerability, though individual responses vary