Standard dose escalation: 0.25 mg weekly for 4 weeks 0.5 mg weekly for 4+ weeks 1.0 mg weekly for 4+ weeks 1.7 mg weekly if needed 2.4 mg weekly (maximum) There is no requirement to reach 2.4 mg if the patient is responding and tolerating treatment
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While the whole TMDs, G s protein, and Nb35 showed decent density, the ECDs of GLP-2R complex structures displayed very poor density in the whole density maps and were thus omitted in the final structural models
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