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The research team of Frias et al designed a 32-week, randomized, double-blind, parallel-group, active control trial that included adults with a diagnosis of type 2 diabetes and a body mass index of 27 and HbA1C levels ranging from 7.5% to 10% despite a daily dose of metformin

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[223] [224] Other neurotransmitters, peptides, hormones, and enzymes Acute amphetamine administration in humans increases endogenous opioid release in several brain structures in the reward system

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