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The nuance is that a large share of autistic patients also show undermethylation traits, where aggressive folate therapy can occasionally activate irritability, anxiety, or sleep disruption

During a pre-soaking step, enzymatic interconversion of folate vitamers takes place in favour of 5-methyl-THF, which is considered the most bioavailable of all the vitamers present in seeds 413

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AA then enters SMCs and pericytes and is converted to 20-hydroxy-eicosatetraenoic acid (20-HETE), causing pericyte depolarization and contraction, ultimately reducing CBF [94]