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[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Di Francesco V., Barazzoni R., Bissoli L., Fantin F., Rizzotti P., Residori L., Antonioli A., Graziani M.S., Zanetti M., Bosello O., et al

In the STEP trials for semaglutide and the SURMOUNT trials for tirzepatide, participants achieved substantial weight loss that far exceeded what most people accomplish through diet and exercise alone

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Weight-based dosing considerations While the standard clinical trial protocols use fixed-dose titration schedules regardless of body weight, some researchers adjust their approach based on body composition

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