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Furthermore, impaired communication between the ER and mitochondria-especially through mitochondria-associated membranes (MAMs)-appears to exacerbate these stress responses, reinforcing the interplay between calcium dysregulation, redox imbalance, and cell death

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( F ) Viability of Pfa1 and xCT OE cells after 72 h of incubation with Tam (0.5 M) and Lipr (1 M), as measured with an ATP assay (left panel) and a PrestoBlue cell viability assay (right panel)