It contains the active substance tirzepatide, which works as a dual GIP and GLP1 receptor agonist to help regulate appetite and increase feelings of fullness by mimicking gut hormones and slowing how quickly food leaves the stomach
Vorokhobina, A
What is the half-life of Retatrutide and how does it affect protocol design
Diabetology & Metabolic Syndrome, 13 (1), 30
Early phase 2 results suggest Eli Lillys triple-agonist retatrutide (GIP/GLP-1/glucagon) is rewriting expectations, showing ~24% mean weight loss at just 48 weeks in Phase 2 trials
Applying discovery metabolomics, we can expand exploration of the GLP-1 metabolic landscape beyond the established measures, to discover and characterize additional biomarkers that may address these limitations and further accelerate GLP-1 agonist development for type 2 diabetes, obesity, and novel indications