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Optimized force field parameters were taken from the CHARMM generalized force field 19 for carbon dioxide, ethanol, isopropanol, ethosuximide and glycerol

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And yes Im following the dosing amount recommended

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The 68-week trial, results of which were published last month in the New England Journal of Medicine, showed mean body weight dropping 13.7% and mean pain scores falling to 41.7 points from a mean of 70.9 on a 100-point scale