J Pharmacol Exp Ther 282(3):15331540 Thompson RA, Isin EM, Li Y, Weidolf L, Page K, Wilson I, Swallow S, Middleton B, Stahl S, Foster AJ, Dolgos H, Weaver R, Kenna JG (2012) In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs
A decreased risk of PD development was also reported to be linked to higher serum UA levels (Sarukhani et al., 2018)
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According to Holst these results meant 'There was no longer any doubt: GLP-1 treatment of type 2 diabetes was extremely promising' (Holst 2024)
That structural gap is one reason the evidence base looks the way it does
Most peptides also require injection, which carries a risk of infection if you dont properly clean and sterilize everything