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Moreover, previous consideration of NMDA receptor antagonism as potential treatment for binge-eating disorder suggests that the weight-lowering benefits linked to GLP-1MK-801 could be the result of a combined impact on both energy homeostasis and disordered eating behaviours 10,14,41

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Notably, they enhance brown adipose tissue (BAT) activity and promote the browning of white adipose tissue (WAT), thereby increasing energy expenditure