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These labs are often focused on bypassing hepatic first-pass metabolism or investigating central nervous system access in relation to hormone analogs

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Use under medical supervision, especially for pregnant or breastfeeding women, and individuals with existing medical conditions

The uptick in NAION-related lawsuits follows the publication of a June 2025 study in JAMA Ophthalmology , which found a significant association between semaglutide use and increased risk of optic nerve damage