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In the second step, glycine is added to the gamma-glutamylcysteine using the enzyme glutathione synthetase to form glutathione

Moreover, the continued presence of viral particles or remnants within the CNS may exacerbate inflammation, causing demyelination and neurodegenerative changes (50, 51), which in turn may trigger neuroinflammation and mental health issues (52, 53)

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While previous studies have provided systematic or narrative reviews examining the relationship between GLP-1RAs and alcohol use, this work represents the first quantitative meta-analysis to synthesize effect estimates across observational cohorts

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