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Freezing causes the delicate proteins in the semaglutide molecule to clump together and break down, which renders the medication ineffective and potentially unsafe for injection

The onset timing correlates with semaglutide's pharmacokinetic profile: absorption occurs over several hours post-injection, peak plasma concentration is reached within 1 to 3 days, and steady-state accumulation occurs after 4 consecutive weekly doses

It helps patients feel fuller for longer, even when eating less food (2, 11)