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Gallbladder Disease: Rapid weight loss combined with altered gut motility can increase the risk of gallstones or cholecystitis (gallbladder inflammation), which presents as sharp pain in the upper right portion of the abdomen

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The researchers plan to repeat the study using other drugs that alter excitation and inhibition whose mechanisms are better understood, says McAlonan

At this point, it all narrows down to your decision-making after considering all the facts

Over time, this creates a not-so-fun feedback loop: harder stools more straining tighter pelvic floor even harder stools