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We used the ICD10Data website to convert the ICD-9 codes used in the Hirsch and Jaff studies to corresponding ICD-10 codes for our analysis based on the 2020 data (ICD-9 codes were replaced by ICD-10 codes in 2015)

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2022;17(2):e0263818

Humans express both cytoplasmic thioredoxin reductase (encoded by the TXNRD1 gene) and mitochondrial (encoded by the TXNRD2 gene)

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In this review, we begin with an abridgement of co-activator involvement in transcriptional circuitry, followed by the regulation of their activity, expression, and multilateral contributions, in several pathophysiological conditions including developmental disorders, metabolic disorders, with special emphasis on cancer