Think of these like telephone wires between houses
Semaglutide induces weight loss in subjects with type 2 diabetes regardless of baseline BMI or gastrointestinal adverse events in the SUSTAIN 1 to 5 trials
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And the medications reduce food cravings, which also may be true for cravings for alcohol and other drugs
One of these studies also failed to identify any change in anxiety-like behavior 162 , while two further studies employing exendin-4 observed an anxiogenic effect following acute administration 158,169
This mechanistic diversity suggests that GLP-1RAs could be repurposed to target complex, multifactorial disorders like schizophrenia, bipolar disorder, and bulimia nervosa, where current treatment options are limited or suboptimal
