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Approximately 40-50% of ER+ breast cancers harbor PI3KCA mutations, which are associated with increased GSH synthesis and resistance to oxidative stress, ultimately reducing the sensitivity of ER+ breast cancer to ferroptosis [21]

Obes Rev 20(6):816828

And real-world patients, the ones living with this medication day to day, sometimes describe mood changes that clinical trial data alone cannot explain

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Several patients have presented with a medical condition called nonarteritic anterior ischemic optic neuropathy (NAION), a non-inflammatory disease of small blood vessels in the anterior portion of the optic nerve