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The evidence base supporting the therapeutic rationale for GLP-1 and GIP receptor agonists in obesity and Type 2 Diabetes (T2D) involves a mix of basic research, translational studies, clinical trials, and real-world evidence

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The researchers emphasize that weight loss associated with GLP-1 drugs has many clear health benefits for people with obesity, type 2 diabetes and heart failure, including improving blood-sugar control, short-term cardiorenal benefits and improvements in survival outcomes

The Phase 2 data is some of the strongest we have seen in this space

CONCLUSION The clinical and preclinical data presented at the ACR Convergence 2025 show both the therapeutic potential and the scientific complexity of GLP-1 agonists in OA

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