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The vagus nerve feeds into the NTS

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While the practice is completely legal, off-label use means that the drug is prescribed for a condition, age, group or dosage outside of its intended Food and Drug Administration (FDA) approval

In accordance, emerging therapies act through diverse mechanisms, such as inhibition of DNA repair enzymes, modulation of neuronal excitability, suppression of purinergic signaling, prevention of cytoskeletal degradation and attenuation of nociceptive transmission, each representing a distinct strategy in addressing the complex pathophysiology of neuropathic pain (Table 4)

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doi: 10.1016/j.bbr.2010.05.033 43 VakalopoulosC