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These extracts caused DNA nicks, apoptosis, and cell cycle arrest in a dose- and time-dependent manner by increasing the production of reactive oxygen species (ROS) and lowering mitochondrial potential [93] possibly by blocking the Protein Kinase C (PKC) [94]

Fishers exact and Mann-Whitney U tests were used for categorical and continuous variables, respectively

NNMT inhibitor compound Class: Small-molecule NNMT (nicotinamide N-methyltransferase) inhibitor Formula / M.W.: C 10 H 11 IN 2 , ~286.11 g/mol (iodide salt)

[iv] Raun K, Hansen BS, Johansen NL, Thgersen H, Madsen K, Ankersen M, Andersen PH

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