The OH groups confer water solubility and the the drug is not able to permeate the predominantly lipid-soluble (fat-soluble) membranes of the GI tract
Clinics that adopt this model often find visits feel less rushed
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vitamin D intake ~20% of recommendations Lean mass risk: protein + calcium insufficiency may contribute, alongside other drivers B-vitamins: thiamine and cobalamin deficits appear to increase over time Clinical takeaway (my approach): GLP-1s dont cause malnutrition in everyone but they can unmask risk in the wrong context (older adults, low-protein diets, restrictive eating patterns, prolonged nausea/vomiting, rapid weight loss, post-bariatric patients)
The reason is the response of your gut hormone called GLP-1
Mice do not develop such nodules but may have focal lesions similar to those in rat hepatodiaphragmatic nodules and with large nuclei with large central nucleoli-like basophilic bodies
