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This pattern reflects the powerful metabolic adaptations that occur during caloric restriction, including decreased resting metabolic rate, increased hunger hormones, and enhanced nutrient absorption efficiency

Prioritizing protein helps preserve muscle mass, maintain strength, and support energy levels as weight changes

Important safety considerations include avoiding use during pregnancy or when planning pregnancy, and monitoring for symptoms of pancreatitis or gallbladder disease

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Curre Res Diabetes & Obes J 2023

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