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Hormone delivery method optimization Before starting a GLP-1 medication, evaluate your HRT delivery method: If you are on oral HRT: Talk to your provider about switching to transdermal delivery (patches or gels) for estrogen, and either a Mirena IUD or transvaginal delivery for progesterone

This conservative starting dose minimizes side effects while allowing your body to adjust to the therapy

"Tirzepatide is an Imbalanced and Biased Dual GIP and GLP-1 Receptor Agonist." JCI Insight, 2020, 5(17), e140532

5 Recommended Rotation Pattern A practical, structured 6-zone rotation covers all approved sites: Left abdomen Right abdomen Left thigh Right thigh Left upper arm Right upper arm Within each region, aim to move at least 1 inch (2.5 cm) from the previous injection point

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