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doi:10.1136/emj.16.2.84

Longevity pathways activated NAD+-dependent enzymes like SIRT1, tied to DNA repair and stress response, become more active

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Firstly the Review was based on research papers that were very suspect and involved groups of individuals that did not represent a wide cross section of society (the primary study was of mainly elderly males)

[9] As a medication it is used to treat low blood sugar, beta blocker overdose, calcium channel blocker overdose, and those with anaphylaxis who do not improve with epinephrine

When taken in moderate, medically supervised doses , it is generally considered safe for most healthy adults