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PROTAC-Mediated HDAC7 protein degradation unveils its deacetylase-independent proinflammatory function in macrophages

Mechanically, astragaloside I directly binds to HDAC3, downregulates the expression of HDAC3, while upregulates the expression of Klotho to block the activation of the TGF-1/Smad2/3 signaling pathway through synergistic inhibition of HDAC3 and TGF-1, thereby mitigating the renal fibrosis process of DKD (Zhang X

Adams MA, Dolan P

& Cohen Tervaert, J

Hajishengallis, G., Lamont, R

La formula si basa su una concentrazione elevata di Copper Peptide (GHK-Cu), combinata con attivi idratanti e funzionali che lavorano in sinergia per rendere la pelle pi compatta, luminosa e levigata