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Furthermore, these membrane-bound and soluble hydrolases may also act as monophosphatases of the diphosphonucleotides, catalyzing the hydrolysis of ThDP to ThMP (Figure 3)

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However, the lower bioavailability may require higher doses or longer treatment periods to achieve comparable results, if achievable at all

10.3389/fphar.2023.1264842 27 BrockmannK.ApelA.SchulteC.Schneiderhan-MarraN.Pont-SunyerC.VilasD.et al (2016)