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They are pure from synthetic compounds that can have significant side effects

This is a fundamentally different type of appetite suppression than what GLP-1 agonists provide

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The group receiving a 0.3 mg dose experienced a 6.0% weight loss, with 0.6 mg there was a 6.8% weight loss, with 1.2 mg there was a 9.1% weight loss, with 2.4 mg there was a 9.7% weight loss, and weigh 4.5 mg there was a 10.8% weight loss, compared with 3.0% weight loss for pooled placebo

The absence of effects in the limited human data does not confirm long-term safety