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Eligibility criteria for these programs may vary

Membrane interactions of S100A12 (Calgranulin c)

1 Previous studies have shown the crosstalk between Ras/ERK and PI3K/AKT pathway and thus inhibition of one pathway may induce activation of the other one

As of March 2026, two trials are actively recruiting new participants: the Maintenance trial (NCT06859268, testing dose reduction after initial weight loss) and a new enrollment trial (NCT07232719, 250 participants with obesity or overweight)

Hydrogen water offers easy consumption, while glutathione relies on internal production

Starting both agents at lower doses than typically used for monotherapy and escalating more slowly can improve tolerability