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The clinical importance is debated
Key lifestyle factors that support long-term results include: Stress regulation and nervous system balance Consistent, restorative sleep Strategic use of intermittent fasting when appropriate Regular resistance training to preserve muscle and insulin sensitivity A whole-food diet with adequate protein and balanced macronutrients Minimizing refined sugars, inflammatory seed oils, and excess alcohol When these foundations are neglected, appetite suppression alone may lead to short-term weight loss without improving metabolic resilienceor may even worsen body composition over time
Wang LY, Liu XJ, Li QQ, Zhu Y, Ren HL, Song JN, et al
A thorough medical history review is essential before starting treatment.
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Preclinical studies suggest GLP-1 agonists may enhance regulatory T cell differentiation and reduce pro-inflammatory cytokine production, potentially supporting immune tolerance
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