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10.1186/s12933-017-0564-0 134 SongG.LiuX.LuZ.GuanJ.ChenX.LiY.et al (2025)

Tendons are notoriously slow to heal, because they barely have a blood supply

This is opposed to oral vitamins that must be digested through the stomach and intestines, with a large percentage broken down or eliminated through urination

The mild increase in DNA fragmentation at 200 g/mL is consistent with the elevated necrosis at that concentration: membrane disruption exposes chromatin to extracellular nucleases and divalent metal ions, accelerating fragmentation independently of ROS 51

Prevention: administer for 2 consecutive days

This can be accomplished by obtaining the first-morning sample of urine and determining the 6SMT level and normalizing it to the concentration of creatinine