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28 In people without diabetes but with obesity and pre-existing cardiovascular disease, 2.4 mg semaglutide once weekly was shown to reduce the risk of a composite of death from cardiovascular causes, nonfatal myocardial infarction or nonfatal stroke by 20% over a median of 3.25 years

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Titration: After 4 weeks, the dose may be increased to 5 mg once weekly

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