By slowing gastric emptying and acting directly on brain receptors that regulate hunger, these medications significantly reduce food intake
Eaton S, Fukumoto K, Stefanutti G, Spitz L, Zammit VA, Pierro A: Myocardial carnitine palmitoyltransferase I as a target for oxidative modification in inflammation and sepsis
In the UK, obesity is thought to cost the NHS 6.1bn per year, government estimates show
Choosing the right pharmacological treatment in these patients remains challenging due to the heterogeneous patient population, patients expectation of the treatment outcome, unavailability of efficacious drugs, and the multifactorial and incompletely understood underlying pathophysiology
To minimize treatment interruptions due to adverse reactions, subsequent Phase III clinical trials may adopt a more gradual dose-escalation strategy to reduce the incidence and severity of gastrointestinal discomfort and other adverse events, thereby enhancing patient tolerance and adherence to the medication
NAD+ is essential for cellular respiration, with roles in glycolysis, the Krebs cycle, and the electron transport chain
