As with other incretin-based therapies, the most commonly reported side effects include nausea, vomiting, diarrhea and constipation, particularly during dose escalation
For example, combinations of GLP-1/glucagon RA achieve more liver fat content reduction in people with MASLD compared to GLP-1 RA alone despite similar WL, likely due to the direct effect of glucagon on hepatic lipid oxidation [79]
GLP-1 receptor activation sends signals of fullness to the brain, slows the rate at which food leaves the stomach, and supports more stable post-meal blood sugar responses
Biochem Pharmacol (2020) 180:114147
On 19 March 2026, the FDA approved a higher-dose formulation of semaglutide, Wegovy HD, at 7.2 mg for once-weekly subcutaneous administration
Your doctor may want to see readings taken at different times of day, as both medications can affect blood pressure variably throughout the day depending on when they are administered and when they reach peak effect