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Reactive astrocytes have been shown to exert cytotoxicity, and as their activation intensifies, astrogliosis contributes to pathological features such as fibril accumulation, vascular damage, and BBB disruption (Liddelow et al., 2017

doi: 10.3389/fphar.2025.1543870 Received 12 December 2024 Accepted 25 March 2025 Published 14 May 2025 Volume 16 - 2025 Edited by Sabrina Petralla, Heidelberg University, Germany Reviewed by Yuan Wei, Jiangsu University, China Shameer Pillarisetti, University of Studies G