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The main organ of VPA metabolism in the human body is the liver, mainly due to the diversity and high activity of biotransformation enzymes there [38]

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Thus, resilience-centered thinking shifts proteostasis therapeutics from single-target correction toward network stabilization or context-specific destabilization, precisely aligned with disease biology

9 Recent population-based studies reported an incidence of statin-induced liver injury of 19 cases per 100,000 per year

In some embodiments, from about 10 mM to about 200 mM concentration of a buffer is present in the gel formulation

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