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Arrange a routine appointment with your GP or diabetes nurse if: Injection site reactions persist beyond one week or worsen progressively You develop a mild rash that does not resolve within a few days Skin changes cause concern or uncertainty about continuing treatment You experience persistent itching without visible rash When consulting your healthcare provider, provide comprehensive information including when the skin changes began, their location and appearance, any associated symptoms, and whether you have started any other new medications or products

Tirzepatide SURMOUNT-1 (2022) and SURPASS-2 (2021) SURMOUNT-1 (Jastreboff et al., NEJM 2022): 2,539 non-diabetic adults with BMI 30, 72 weeks of tirzepatide 15 mg/week: Weight loss: 20.9% (vs 3.1% placebo) 91% of participants 5% loss, 56.7% 20% SURPASS-2 (Fras et al., NEJM 2021): 1,879 T2D patients head-to-head vs semaglutide 1 mg: HbA1c: 2.30% (tirzepatide 15 mg) vs 1.86% (semaglutide) Weight loss: 11.2 kg vs 5.7 kg Tirzepatide statistically outperforms semaglutide on both HbA1c and weight in a head-to-head trial a rare outcome in incretin pharmacology
But its not definitive yet
They always offer alternatives and suggestions
43%