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NRIs clinical trials incorporate meticulous monitoring protocols, dose-optimization strategies, and individualized risk assessments to ensure that participants receive maximal benefit with minimal adverse effects

Published in NEJM in 2022, SURMOUNT-1 randomized 2,539 adults with obesity (BMI 30) or overweight (BMI 27) with weight-related conditions, without diabetes, to tirzepatide 5mg, 10mg, 15mg, or placebo, alongside diet and exercise