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NOX isoforms are already known to be overexpressed in multiple malignancies, making them potential therapeutic targets in cancer [230]

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Moreover, the accumulated succinate is released from the heart into the circulation at reperfusion 59 , potentially activating the G-protein-coupled succinate receptor (SUCNR1) signaling and engaging inflammatory signaling 60

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In this case the liposomes keep glutathione in its reduced, or biologically active state