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Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris

& Lesich, K

Supplementary Materials The following supporting information can be downloaded at: Table S1

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Pregnancy per cycle 15-25% under 35, lower with age

Importantly, the absence of substantial protection in experimental AP after genetic MCU ablation does not negate the pathogenic role of mitochondrial calcium overload, but rather indicates that MCU-dependent matrix Ca 2+ uptake is not the sole determinant of disease severity