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Curr Opin Psychiatry (2015) 28(1):16

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For the estimated 1.5 million Americans living with lupus, and millions more worldwide, conventional treatments often involve a difficult tradeoff: suppress the immune system broadly to reduce attacks on healthy tissue, but leave the body vulnerable to infections and long-term complications

However, a large randomized trial found no improvement in semen quality or live birth with folic acid and zinc supplementation

It says nothing about intestinal permeability, portal absorption, hepatic first-pass metabolism, or systemic distribution