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Caution applies for individuals with cardiovascular conditions, though topical application minimizes systemic exposure

Pregnancy significantly affects the thyroid gland, and female infertility has been closely linked to thyroid disturbances

Both the combined results of the IVW method (OR common-effect-model = 0.43 [95%CI 0.260.72], OR random-effects-model = 0.42 [95%CI 0.240.76]) and the SMR method (OR common-effect-model = 0.97 [95%CI 0.960.99], OR random-effects-model = 0.97 [95%CI 0.951.00]) showed the consistent trend with the separate results(Fig

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