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In the Phase 2 trial at 48 weeks (NEJM 2023): Every single participant on 12 mg lost at least 5% of their body weight

Further studies have shown that GLPs have the ability to boost levels of PI3K, p-Akt, eNOS, and NO inside the aorta, thereby significantly improving endothelium-dependent aortic diastolic function and alleviating endothelial dysfunction (Zhu et al., 2014)