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For example, serum levels of the proteoglycan glypican-3 in some patients with hepatocellular carcinoma are elevated through the shedding of glypican-3 from cell surfaces, which interferes with the efficacy of glypican-3-targeted therapy 3
In the late 19th century, MB was repurposed from textile dye to medical therapy: in 1891, Paul Ehrlich and colleagues employed it as an antimalarial treatment, demonstrating that a chemical dye could function as a therapeutic agent
The cause of infertility remains unexplained in many cases despite diagnostic advances
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If acyl-carnitine abnormalities were confirmed, non-mitochondrial disorders of fatty-acid metabolism were ruled-out before a MD workup was initiated
