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Yes, a glutamine deficiency can occur in the body

This narrative review summarizes the mechanisms of action, clinical efficacy, safety profiles, and sex-specific outcomes associated with SGLT2i and GLP-1 RAs

N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

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10.1016/s0896-6273(00)80169-5 91 MillerK

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