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The first is IV infusion

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Progress in vesicular formulations, including ultra-deformable liposomes (transfersomes and ethosomes), has enhanced skin permeability by allowing the vesicles to go across intercellular routes in the stratum corneum under osmotic gradients or ethanol-induced lipid fluidisation [258, 281]

However, accelerated facial aging is a well-documented consequence of rapid weight loss, previously described in the context of bariatric surgery, primarily due to fat volume depletion and reduced skin elasticity