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Different forms of cell death are closely related, and there are overlapping molecular regulatory pathways between ferroptosis and other cell death modes, such as necroptosis, apoptosis, pyroptosis and autophagy, collectively playing a role in CKD

Cognitive and Brain Support The brain is highly susceptible to oxidative stress because it consumes a large amount of oxygen

The excess production of nitric oxide generates nitric oxide (NO ) and peroxynitrite anion (ONOO ) radicals (Fig

In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

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