Kristina screens for absolute contraindications such as personal or family history of medullary thyroid carcinoma, MEN2, severe gastroparesis, pregnancy, or breastfeeding before starting therapy
May create a dependency, leading to lazy bowel
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The FDA cleared orforglipron for chronic weight management in adults with obesity, or overweight with at least one weight-related comorbidity, based on the ATTAIN clinical program which showed placebo-adjusted weight loss of 7.5% to 11.2% in non-diabetics (ATTAIN-1) and 5.1% to 9.6% in diabetics at different doses, along with the expected glycaemic benefits (ATTAIN-2)
Those two events converged to make the Canadian generic route the clearest lower-cost option available
The side effects I tell every patient about Early in my experience, I had a patient using PT-141 who didnt call me after his first dose